Failure of optimized dual proton pump inhibitor amoxicillin therapy: What now?
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چکیده
منابع مشابه
Failure of optimized dual proton pump inhibitor amoxicillin therapy: What now?
For a decade following the initial description of dual amoxicillin–proton pump inhibitor (PPI) therapy by Unge et al.,[1] investigators attempted to optimize the doses and duration of this regimen in an attempt to reliably achieve >90% cure rates (reviewed in Dore et al.).[2] When given twice daily PPI and amoxicillin cured approximately 62% patients (range 60–64%),[3] and increasing the omepra...
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The aim of this study was to compare the efficacy and tolerability of the first-line Helicobacter pylori (H. pylori) eradication regimen composed of proton pump inhibitor, clarithromycin, and amoxicillin, with those of a regimen composed of proton pump inhibitor, metronidazole, and amoxicillin. Data of patients, who were administered the first-line H. pylori eradication regimen at Tokyo Medical...
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Background\Aim: Quadruple daily administration of proton-pump inhibitor (PPI) therapy achieves potent acid inhibition, and combined with amoxicillin, with its pharmacodynamic and pharmacokinetic characteristics, may be efficient for Helicobacter pylori eradication. We compared the efficacy of two optimized high-dose dual therapies with a bismuth-containing quadruple regimen for treating H. pylo...
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Proton pump inhibitors (PPIs) have been established as the new "gold standard" for traditional acid-inhibitory treatment of the so called "peptic" diseases. Due to the high antisecretory and ulcer-healing potency of omeprazole, no major improvements of the efficacy in ulcer healing and pain relief can be expected. Pantoprazole, as a further development in PPIs, is characterized by improved phar...
متن کاملassociation of proton pump inhibitor therapy with hepatic encephalopathy in hepatitis b virus-related acute-on-chronic liver failure
conclusions the occurrence of he is associated with hyponatremia and ppi use in patients with aclf. results in univariate analysis, patients with he in aclf had a significantly higher rate of ppi use (89.1%) compared with non-he (63.6%, p = 0.001). in addition, clinical and standard laboratory variables were significantly different between the two groups regarding the infection rate, hyponatrem...
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ژورنال
عنوان ژورنال: Saudi Journal of Gastroenterology
سال: 2017
ISSN: 1319-3767
DOI: 10.4103/sjg.sjg_292_17